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Senescence¬†is ‚Äėthe condition or process of deterioration with age. The loss of a cell's power of division and growth.

Negligible senescence is a term to denote organisms that do not exhibit evidence of biological aging (senescence), such as measurable reductions in their reproductive capability, measurable functional decline, or rising death rates with age.

In this post:

  1. Getting older without getting old
  2. Caloric restriction mimetics
  3. Prebiotics: What you should know
  4. Slow sex, long life
  5. Omega-3 supports healthy ageing


1. Getting older without getting old 

Ageing is not a biological inevitability. Scientists are studying every aspect of the body which could lead to treatments that could slow down, or even stop, the ageing process.

Ageless: The New Science of Getting Older Without Getting Old by Andrew Steele is a guide to the science behind the most important biomedical question of our time: why we get old, and how we can stop it.

Considering that the available literature suggests that their outstanding stress resistance is linked to maintenance of protein homeostasis and robust mitochondrial functions, treatments that target protein modification and upregulation of matrix antioxidants may have implications for extending human health span. [Source]


Related: Biohacking for Longevity: 4 Ways to Stay Healthy All Throughout Life


 2. Caloric restriction mimetics

Caloric restriction is one of the most well-researched interventions for improving health and lengthening lifespan. Caloric restriction might exert its anti-ageing properties by limiting senescent cell accumulation.

caloric restriction and longevity

Image source: Tucci P. Caloric restriction: is mammalian life extension linked to p53?

What if you could have the benefits of a restricted diet without actually restricting your diet?

A new class of innovations known as caloric restriction mimetics has emerged that allow people to enjoy the benefits of caloric restriction. These benefits are purportedly: reversing the ageing process and improve health without extreme dietary restrictions that could take away from the enjoyment of life.

Read the full article


3. Prebiotics: What you should know

probiotics vs prebiotics vs postbiotics

Prebiotics are distinct from probiotics and postbiotics, so understanding the differences between these is crucial.

While prebiotics feed the bacteria in our gut, they do not contain any live bacteria. Probiotics, on the other hand, are live microorganisms that inhabit the microbiome. Like prebiotics, probiotics may confer health benefits when consumed in sufficient amounts.

An example of a probiotic is Akkermansia muciniphila, which accounts for up to 5% of total intestinal bacteria. A. muciniphila has gained considerable interest in recent years due to its health-promoting effects. For instance, A. muciniphila is inversely associated with conditions such as diabetes, obesity, and cardiometabolic disease.

Finally, postbiotics are products of prebiotic and probiotic activity. An example of a postbiotic is butyrate, a short-chain fatty acid (SCFA) produced through prebiotic fermentation.

Read the full article


4. Slow sex, long life

Tokyo’s imperial archives advise what science now confirms: the secret of longevity lies in the gentle arts of the bedroom.

Utamakura (Poem of the Pillow)

Utamakura (Poem of the Pillow)
Source: The Trustees of the British Museum

Spermidine is an anti-aging metabolite that exerts its effects through the translational control of autophagy. Spermidine protects mitochondrial DNA. [Source]

Spermidine intracellular concentration declines during human ageing. Supplementation with spermidine markedly extended the lifespan of human immune cells. [Source]

Mitochondria are the energy powerhouses of cells. It was the American biologist Lynn Margulis who first championed the theory that mitochondria were once independent microbes that joined other cells through the process of symbiogenesis to form the complex organisms we see around us today. More recently, a host of new studies reveal that spermidine guards against ageing of mitochondria. If spermidine prevents dysfunction in our mitochondria, the basis of cellular energy, then it stands to reason that it may protect human longevity as well.

And protecting mitochondria is just the start. Scientists have recently discovered that spermidine can prevent an additional four negative hallmarks of ageing:

  • epigenetic changes that damage gene expression;
  • impaired maintenance of proteins;
  • impaired production of stem cells;
  • disruption of intercellular communication.

Emerging research suggests it may also inhibit cellular senescence [Source].

Read Aeon article | Watch Oxford Longevity Project webcast

Shop for Spermidine at OptimOZ


5. Omega-3 supports healthy ageing

Omega 3 sources

The cardioprotective effects of Omega-3s are pretty well established. But the research on Omega-3s has also revealed that they're involved in nearly every aspect of human health, eliciting some unconventional effects that influence neurocognitive, immunological, and respiratory health, and lots more ‚Äď throughout the lifespan.

Rather than focusing on decreasing Omega-6 intake to improve the ratio, most people would probably benefit from increasing Omega-3 intake instead to improve overall blood concentrations. 



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