Biohacking Weekly 43: What’s Inside Mark Hyman’s Supplement Stack?

This is Biohacking Weekly - A curated news roundup designed to help you increase your longevity, improve healthspan and access OptimOZ product picks.

IN THIS EDITION

1. "Mind after midnight" theory
2. Aging takes a sharp turn at 50
3. Mark Hyman’s daily supplement stack
4. The rise of Urolithin A in sports nutrition
5. How nature sharpens your focus

1. 🌃 Mind After Midnight: Late-Night Choices Sabotage Your Mental Edge

Ever notice how late-night decisions feel riskier? Stanford Medicine’s “mind after midnight” theory explains why: after midnight, your brain makes choices it wouldn’t at noon, spiking risks for anxiety and depression.

Poor sleep doesn’t just drain energy — it clouds emotional control. Research shows insomnia increases anxiety risk 17-fold, and sleep apnea triples mood disorder odds.

To counter the “mind after midnight” effect, stick to a consistent sleep schedule, skip caffeine after noon to sync your circadian rhythm and avoid screens before bed. Early bedtimes, even for night owls, cut mental health risks, per Stanford’s findings. By prioritizing quality sleep, you’re not just resting — setting the stage for a healthier, longer life.

Read the full article on Stanford Medicine

Don’t let poor sleep dull your edge!

Struggling with late-night brain fog that clouds your decisions? Stanford Medicine warns that poor sleep can amplify anxiety and depression, dimming your mental spark.

OptimOZ carefully  curated sleep collection  — featuring trusted names like  BIOptimizers, Bulletproof,  Neurohacker Collective,  — helps restore calm, deepen rest, and wake up sharper.

2. ⏳ Study Reveals Body’s Aging Accelerates Around 50

A recent study has pinpointed a critical window when the human body begins aging more rapidly — around age 50. Researchers found that organs and tissues undergo a “molecular cascade storm” between ages 45–55, with sharp increases in proteins linked to diseases like cardiovascular disease, fatty liver, and fibrosis.

To better understand this, scientists created a detailed “map of aging” by studying tissue samples from people of different ages. They found that around 50, the body experiences a surge of internal changes that affect multiple systems at once. Experts believe this knowledge could help medicine shift from only treating age-related diseases after they appear to focusing on ways to slow down aging before it causes serious health issues.

Read the full article on Medical News Today

3. 💊 Inside Mark Hyman’s Daily Supplement Routine for Longevity

Renowned functional medicine physician Dr. Mark Hyman focuses on extending healthspan, not just lifespan. His supplement routine — far from random — is built on science-backed tools to keep him sharp, resilient, and full of vitality each day.

At the core of his daily stack is a high-quality multivitamin and vitamin D3 with K2, covering nutrient gaps while boosting bone strength, mood, and immunity. To combat inflammation and protect the brain, he relies on omega-3 fish oil and curcumin, while a probiotic and NMN support gut health and mitochondrial function. Stress and recovery are covered with C15:0 fatty acid, NAC (N-acetylcysteine), and ashwagandha, while a methylated B-complex keeps energy metabolism and detox pathways running smoothly.

Read the full article on Routines

4. 🚴 Urolithin A Could Redefine Supplements for Athletic Performance

A new review spotlights Urolithin A (UA), a gut-derived compound from pomegranates and nuts, as a promising sports supplement. Unlike many products with narrow effects, UA supports bone strength, joint health, muscle endurance, and oxygen uptake by boosting mitochondrial energy and fat metabolism. Early studies in older adults and trained athletes show gains in endurance, strength, and cardiovascular efficiency, suggesting UA could bridge anti-aging science with athletic performance.

UA has proven safe at doses up to 2,000 mg, with optimal benefits around 1,000 mg daily. Research indicates it may help protect bones, reduce exercise-related inflammation, and guard the heart from fatigue. Its effects also appear independent of diet, making it a practical addition to training routines.

Read the full article on Frontiers

5. 🌳 A Surprising (and Easy) Way to Boost Your Attention Span

A simple walk in the park may be one of the easiest ways to boost attention and memory. In a University of Michigan study, students who walked 2.8 miles (4.5 km) through nature improved test scores by nearly 20%, compared to only slight gains after walking the same distance in a busy city.

The benefits didn’t depend on mood or weather — even a cold winter stroll sharpened focus. Researchers call this “attention restoration,” the idea that daily focus gets depleted but is replenished in natural settings. Scientists believe the secret lies in nature’s “soft fascination”: ocean waves, wildflowers, or a river’s curve gently engage the brain without overstimulation.

Read the full article on The New York Times