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Mitigating Aging with Urolithin A, HMOs and Probiotics
LayerOrigin's MitiAging bundle combines cutting-edge microbiome science to tap into Urolithin A—a proven longevity molecule that most people's guts don't produce efficiently.
"The idea of improving one's microbiome to slow aging has gained attention. Urolithin A is a 'postbiotic rockstar' in the longevity space with studies published in top-tier journals such as Nature and Cell – with 11 compelling human clinical trials."
— Dr. Kara Fitzgerald, Functional Medicine Physician & Epigenetics Researcher
However, Dr. Fitzgerald also stresses the microbiome aspect: only a minority of people naturally produce Urolithin A in high amounts, so many of us might benefit from either dietary strategies or supplementation to obtain it.
LayerOrigin's MitiAging bundle is essentially one such strategy combining both approaches. Dr. Fitzgerald's commentary underscores why a product like this exists: leveraging cutting-edge microbiome science to tap into a proven longevity molecule (Urolithin A) that most people's guts don't output efficiently.
Understanding Ellagic Acid: The Urolithin A Precursor
🧬 Mechanism of Action
Ellagic acid is a polyphenolic compound found in pomegranate, berries, and nuts. On its own, ellagic acid has antioxidant and anti-inflammatory properties, but its unique anti-aging relevance is as a precursor to Urolithin A.
In the colon, certain gut bacteria metabolize ellagic acid (and related ellagitannins) into Urolithin A – a postbiotic metabolite that can enter circulation and benefit cells.
Urolithin A's primary mechanism: Activation of mitophagy (selective recycling of damaged mitochondria) which improves mitochondrial function and cellular energy production. This clearing-out of dysfunctional mitochondria helps counteract age-related declines in cellular function.
Scientific Evidence for Urolithin A
Triggers mitophagy via the PINK1/Parkin pathway
Extended lifespan in C. elegans studies
Improved muscle function in rodent models
Enhanced muscle endurance in older adults
Improved mitochondrial biomarkers in humans
Reduced inflammation and cellular stress
1 in 3
people can naturally produce Urolithin A effectively
Not everyone's microbiome can convert ellagic acid effectively. Diet influences this: high-fiber, plant-rich diets associate with more Urolithin producers than low-fiber Western diets. A study found that at baseline only 12% of participants had detectable Urolithin A after drinking pomegranate juice, though this rose to 40% after repeated dosing – implying 60% remained non-producers.
⚡ The MitiAging Approach
The MitiAging approach provides abundant ellagic acid and alters the gut environment (with HMOs and probiotics) so that even "non-producers" may develop a Urolithin-producing microbiome. This strategy is novel but biologically plausible: feeding ellagic acid alongside prebiotics could encourage the growth of microbes that metabolize it into Urolithin A.
Human Milk Oligosaccharides (HMOs): Gut Health Revolutionaries
What are HMOs?
HMOs are specialized complex sugars originally found in human breast milk. The MitiAging bundle provides five HMO types – 2'FL, LNnT, LNT, 3'SL, and 6'SL – produced by fermentation. These oligosaccharides are indigestible by human enzymes but serve as prebiotic fuel for specific beneficial gut bacteria.
Key Research: HMOs selectively nourish gut bacteria like Bifidobacterium and Akkermansia, promoting healthier microbiome composition and improved gut barrier integrity.
Anti-Aging Evidence
A 2022 mouse study tested 2'-fucosyllactose (2'FL) in an accelerated-aging model with striking results: reduced oxidative stress and inflammation, improved gut barrier function by activating SIRT1 and Nrf2 pathways.
Brain Benefits: 2'FL supplementation protected the brain – reducing neuronal death in aging mice and increasing SIRT1 expression in brain tissue, supporting the gut-brain axis connection.
HMOs "significantly improved gut barrier function and SCFA levels in aging mice," and even inhibited inflammation and oxidative damage beyond the gut. These preclinical findings support HMOs' potential to promote a youthful gut environment.
Role in Urolithin A Production
By fostering a healthier, more diverse microbiome, HMOs may indirectly boost Urolithin A production capacity. Feeding bifidobacteria and Akkermansia creates conditions that favor colonization of Urolithin-producing microbes, which often co-exist in a fiber-rich, probiotic-friendly gut.
Probiotics: Seeding Your Microbiome for Success
What's Included
The bundle's probiotic component provides 10 strains of Lactobacillus and Bifidobacterium (3 Bifido + 7 Lacto strains, 40 billion CFU total per full daily dose). It includes clinically studied strains for gut health like Bifidobacterium longum, B. lactis, Lactobacillus rhamnosus, and L. acidophilus.
These strains are freeze-dried cultures in the Gut Biome Restore capsules, alongside HMOs and 250mg of resistant corn starch (a prebiotic fiber).
🔬 Important Note on Urolithin-Producing Bacteria
There is no single "Urolithin A probiotic" commercially available, because the microbes known to produce Urolithin A (e.g. Gordonibacter urolithinfaciens, recently reclassified as Ellagibacter) are anaerobes not yet used as dietary probiotics.
Instead, MitiAging takes a broad-spectrum approach: by enriching the gut with friendly bacteria and prebiotics, it creates an ecosystem where Urolithin-producing microbes can naturally bloom or be supported from minor populations already present.
The probiotic + prebiotic combination in Gut Biome Restore is designed to "train" your microbiome to get the most out of the ellagic acid – essentially an attempt to bioengineer your gut into a Urolithin factory.
The Science Behind Anti-Aging Claims
Mitochondrial Support: Urolithin A is the first known compound shown to activate mitophagy in humans, improving cellular energy and longevity
Gut Microbiome Health: HMOs and probiotics restore youthful gut microbiota, reducing inflammation and improving metabolic markers
Anti-Inflammatory Effects: Ellagic acid, Urolithin A, and HMOs all have documented anti-inflammatory properties
Cellular Protection: Activates SIRT1 and Nrf2 pathways, supporting the body's natural antioxidant defenses
4 months
of Urolithin A supplementation significantly improved muscle endurance in older adults
Better than Synthetic Urolithin A?
One bold claim is that inducing your own Urolithin A is superior to just taking Urolithin A pills, because it could lead to sustained benefits even after stopping. The argument is that by feeding Urolithin-A-producing bacteria, your gut gains the capacity to keep making Urolithin A in the future.
This "microbiome training" program is an intriguing hypothesis. If successful, one might maintain higher Urolithin levels from diet alone after the supplement course, though this remains to be clinically demonstrated.
MitiAging Bundle: Product Overview
🧪 What You Get
Mitochondrial Restore & Revive™
Pomegranate extract standardized for ellagic acid (500mg per capsule) – natural precursor to Urolithin A
Gut Biome Restore™
5 HMOs (250mg total), 10 probiotic strains (40 billion CFU), plus resistant starch (250mg) as prebiotic fiber
Dosage Protocol
Start with 1 capsule of each daily for ~1 week, then increase to 2 capsules of each daily (full 30-day cycle)
Daily Intake (Full Dose)
~1000mg ellagic acid, 500mg HMO blend, 500mg resistant starch, 40 billion CFU probiotic mix
The MitiAging bundle is grounded in sound science. Consumers should be patient and observant for subtle improvements (better workout recovery, more regular digestion, increased energy) rather than expecting a dramatic "anti-aging miracle" overnight.
Experience the MitiAging Revolution
Ready to train your gut to produce nature's most powerful anti-aging compound? The MitiAging bundle combines cutting-edge microbiome science with proven longevity research.
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