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Magnesium, Insulin Resistance, Prediabetes and Diabetes

by Kunal K April 18, 2024 3 min read

It takes 10-15 years or prediabetes before clinical Type 2 diabetes is typically diagnosed. That is to say, it takes years of overconsumption of simple carbs, processed foods combined with a high stress (sympathetic-dominant) lifestyle. It's a long process with plenty of time to intervene and change before the body (and mind) break down irreversibly.

Magnesiun Deficiency May Accelerate Progression of Prediabetes to Diabetes


A 2017 study highlighted that higher magnesium levels could potentially lower the risk of prediabetes and type 2 diabetes among adults, suggesting a link between magnesium, glucose metabolism, and inflammation related to diabetes development. For more details, refer to the study here.


A 2017 systematic review focusing on Insulin Resistance found that magnesium supplementation impacts serum fasting glucose concentrations and fasting insulin levels, More details: PubMed. 


A later study in 2020 study provides conclusive evidence on the association between magnesium intake and the risk of type 2 diabetes (T2D), as well as the impact of magnesium supplementation on glucose metabolism. It found that higher magnesium intake is linked to a 22% reduced risk of T2D, with each 100 mg/day increase in intake lowering risk by 6%. Magnesium supplementation significantly improved various glucose metabolism parameters in individuals with T2D or at high risk. This underscores the potential benefits of magnesium for glucose regulation and T2D prevention. The study: PubMed.


The 2014 study found that higher magnesium intake is associated with a lower risk of impaired glucose and insulin metabolism, as well as a reduced risk of progressing from prediabetes to diabetes among middle-aged people. It suggests magnesium's beneficial role in offsetting the risk of developing diabetes, especially for those at high risk. The study: PubMed.

The 2011 meta-analysis reviewed prospective cohort studies to evaluate the link between magnesium intake and type 2 diabetes risk. The analysis, encompassing 536,318 participants and 24,516 cases, found a significant inverse relationship between magnesium intake and diabetes risk. The study concluded that increased magnesium intake is associated with a lower risk of type 2 diabetes in a dose-response manner. The study: PubMed.


A 2021 meta-analysis investigated the association between serum magnesium levels and prediabetes, revealing that individuals with prediabetes have significantly lower serum magnesium levels compared to healthy controls. This suggests that magnesium deficiency might play a role in the development and progression of prediabetes. For more detailed information, please visit the study on Nature.


A 2022 study explored the effect of oral magnesium supplements on cardiometabolic markers in individuals with prediabetes. Conducted as a double-blind randomized controlled trial over 12 weeks, it compared the effects of magnesium oxide (250 mg/day) with a placebo on various health markers. The study found that magnesium supplementation significantly increased HDL-cholesterol levels but did not significantly affect other cardiometabolic markers such as blood glucose, insulin, and blood pressure at the given dosage and duration. For more details, visit: PubMed.


The 2022 study analyzed the association between dietary magnesium intake and prediabetes risk in childbearing women (18–44 years), utilizing data from the China Nutrition and Health Surveillance (2015–2017). It found that higher dietary magnesium intake was significantly associated with lower fasting plasma glucose levels and reduced odds of prediabetes.

The study suggests a threshold dietary magnesium intake of 410 mg/day beyond which the risk of prediabetes does not decrease further, emphasizing the importance of magnesium intake in prediabetes prevention. The study is here.


A 2015 double-blind placebo-controlled randomized trial demonstrated that oral magnesium supplementation improves glycemic status in adults with prediabetes and hypomagnesemia. The study found significant decreases in fasting and post-load glucose levels,  For more detailed information, see PubMed.

Kunal K
Kunal K

Co-Founder, OptimOZ.com.au

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