


Primeadine GF gluten-free spermidine supplement
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Gluten-Free Spermidine Supplement · Whole-Food Blend · 60 Capsules
Primeadine® GF by Oxford Healthspan
A capsule supplement made from a whole-food blend of chlorella, Shikuwasa citrus skin, and turmeric root, sourced and manufactured in Okinawa, Japan. Provides 1.2 mg of plant-derived spermidine per 2-capsule serving.
Gluten-free. Soy-free. Suitable for vegans and vegetarians. Zero fillers, binders, or flow agents.
About Spermidine
Spermidine is a polyamine — a small organic compound made up of carbon, hydrogen, and nitrogen. It is naturally present in many foods including wheat germ, aged cheeses (particularly blue cheese), mushrooms, soybeans, legumes, some shellfish, and various meats.
Spermidine is also produced by the body itself and by certain bacteria in the gut. Dietary intake from food and supplements adds to the body's overall polyamine content.
Why the Gluten-Free Formulation
The original Primeadine formula is made from concentrated wheat germ extract — wheat germ being one of the richest natural food sources of spermidine. However, wheat germ contains gluten, which makes the Original unsuitable for people who avoid gluten.
Primeadine GF was developed as a gluten-free alternative using a whole-food blend of three ingredients that naturally contain spermidine, sourced from Okinawa, Japan.
The Whole-Food Blend
Chlorella
A single-celled freshwater green algae. Cultivated in outdoor pools in Okinawa. Contributes to the natural spermidine content of the blend and provides a range of naturally-occurring nutrients.
Shikuwasa Skin (Citrus depressa)
A small green citrus fruit native to Okinawa and Taiwan, traditionally used in Okinawan cuisine. The skin naturally contains nobiletin, a polymethoxylated flavone characteristic of citrus peel. Contributes to the polyamine content of the blend.
Turmeric Root (Curcuma longa)
A rhizome from the ginger family, widely used as a culinary spice and food ingredient. Sourced from Okinawa. Contributes naturally-occurring curcuminoids to the blend.
Polyamines in the Blend
In addition to spermidine (1.2 mg per serve), the whole-food blend naturally contains putrescine, another polyamine present in many foods.
Both spermidine and putrescine are members of the polyamine family — small organic compounds naturally occurring in all living cells and in a wide range of dietary foods.
Naturally-Occurring Nutrients
Because this product is a whole-food blend rather than an isolated compound, it naturally contains trace amounts of a range of nutrients from the source foods:
- Vitamin D2
- Vitamin K
- Folate
- Vitamin B12
- Biotin
- Pantothenic acid
- Iron
- Lutein
Refer to the Supplement Facts panel on the bottle for exact per-serving amounts of each nutrient.
Original vs GF: Which to Choose
| Primeadine GF (this product) | Primeadine Original | |
|---|---|---|
| Source | Whole-food blend (chlorella, Shikuwasa, turmeric) | Concentrated wheat germ extract |
| Spermidine per serve | 1.2 mg (2-capsule serve) | 1 mg standardised (3-capsule serve) |
| Gluten | Gluten-free | Contains wheat (gluten) |
| Vegan | Yes | Yes |
| Soy | Soy-free | Soy-free |
| Made in | Okinawa, Japan | USA / Europe |
Choose GF if you avoid gluten in your diet, prefer a whole-food blend over an extract, or want the vegan whole-food option. Choose Original if you don't need to avoid gluten and prefer a higher-concentration wheat germ extract at a lower cost per milligram of spermidine.
Product Specifications
| Format | Vegetable cellulose (hypromellose) capsules |
| Capsules per Bottle | 60 (30 servings at 2 capsules) |
| Serving Size | 2 capsules |
| Spermidine per Serve | 1.2 mg (plant-derived) |
| Ingredients | Chlorella, Shikuwasa (Citrus depressa) skin, turmeric root. Hypromellose capsule. |
| Fillers / Binders / Flow Agents | None |
| Made In | Okinawa, Japan |
| Batch Testing | Every batch tested for spermidine content |
| Dietary Suitability | Gluten-free · Soy-free · Vegan · Vegetarian |
| Storage | Store in a cool, dry place. Keep tightly closed after opening. |
Directions for Use
Take 2 capsules daily, preferably before 2pm.
Capsules can be swallowed whole with water, or opened and the contents mixed into a cold or room-temperature drink or smoothie.
Refer to the bottle label for full directions. Do not exceed the recommended daily intake.
Good to Know
What is a polyamine?
Polyamines are small organic compounds made up of carbon, hydrogen, and nitrogen, with multiple amine (nitrogen-containing) groups. They are present in all living cells and naturally occur in a wide range of dietary foods. Spermidine and putrescine are two members of the polyamine family.
What is Shikuwasa?
Shikuwasa (Citrus depressa) is a small green citrus fruit native to Okinawa and Taiwan. It has a tart, tangy flavour and has been used in Okinawan cuisine for centuries in dishes, juices, and seasonings. The skin, used in Primeadine GF, is naturally rich in nobiletin (a polymethoxylated flavone).
Why sourced from Okinawa?
Oxford Healthspan chose Okinawa as the sourcing and manufacturing region for the GF formula because it grows and cultivates all three whole-food ingredients (chlorella, Shikuwasa, turmeric) locally. This allows the blend to be produced end-to-end from a single geographical region.
Is this product suitable for vegans?
Yes. All three ingredients (chlorella, Shikuwasa, turmeric) are plant-based, and the capsule shell is vegetable cellulose (hypromellose). Suitable for both vegans and vegetarians.
How does the spermidine content compare to food?
1.2 mg of spermidine per serve is roughly comparable to eating a modest amount of high-spermidine foods such as aged blue cheese, mushrooms, or wheat germ. Because polyamine content varies significantly between foods and even between batches of the same food, supplements like this offer a consistent per-serve amount.
Can I take this alongside other supplements?
Primeadine GF is a whole-food supplement and is generally compatible with most other supplements. If you take prescription medication or have any pre-existing medical condition, consult a qualified healthcare practitioner before adding new supplements to your routine.
Important Information
Dietary supplement. This product is a food supplement and is not a substitute for a varied, balanced diet.
Adult use only. Not recommended for children, infants, or use during pregnancy or breastfeeding without medical supervision.
Always read the label and follow the directions for use. Do not exceed the recommended daily intake. Use only if the seal is intact. Keep out of reach of children.
Consult a qualified healthcare practitioner before use if you take prescription medication, are recovering from surgery, are pregnant or breastfeeding, or have any pre-existing medical condition. Discontinue use and consult a practitioner if any adverse reaction occurs.
This product is not intended to diagnose, treat, cure or prevent any disease.
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