Cordycepin is a bioactive compound found in Cordyceps sinensis, one of the most well know medicinal mushrooms today. It has been studied extensively for its immunomodulatory effects. Here are some significant findings from recent research:
image source: https://www.mdpi.com/1420-3049/25/12/2735
Immunoregulatory Effects: Cordycepin was shown to up-regulate IL-10, IL-1beta, IL-6, IL-8, and TNF-alpha while suppressing the production of IL-2, IL-4, IL-5, IFN-gamma, and IL-12 in peripheral blood mononuclear cells (PBMCs). This suggests cordycepin's capability to modulate immune responses selectively (Zhou et al., 2008).
Cordycepin and Immunomodulation: A comprehensive review of Cordyceps militaris extracts, including cordycepin, found differential effects on immune response modulation, with total extracts and polysaccharides promoting type 1 immunity, while cordycepin favored type 2 immunity. This categorization provides insight into the specific immunomodulatory actions of different Cordyceps components (Lee et al., 2020).
Interleukin-10 Production: Another study highlighted cordycepin's potential in selectively up-regulating interleukin-10 (IL-10) production and its mRNA expression, demonstrating its role in controlling autoimmune diseases and its capacity as an immunomodulatory drug (Zhou et al., 2002).
Anti-inflammatory Mechanism: Cordycepin showed anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by suppressing the production of pro-inflammatory mediators. This was achieved through the inhibition of NF-κB activation, mitogen-activated protein kinases (MAPKs), and Toll-like receptor 4 signaling pathway (Choi et al., 2014).
Inhibition of Inflammation and ER Stress-Associated Apoptosis: Cordycepin has been found to protect against glutamate-induced oxidative toxicity and ER stress-associated apoptosis in hippocampal HT22 cells, suggesting its neuroprotective properties (Jin et al., 2014).
Suppression of NF-kappaB through Akt and p38 Inhibition: A study demonstrated that cordycepin inhibits inflammation by suppressing NF-kappaB activation through the inhibition of Akt and p38 in RAW 264.7 macrophage cells, indicating a potential therapeutic approach for inflammation-associated disorders (Kim et al., 2006).
Anti-inflammatory Effects of Cordycepin: A review highlighted cordycepin's protective effects against various diseases associated with inflammatory injury, including acute lung injury, asthma, rheumatoid arthritis, Parkinson's disease, hepatitis, atherosclerosis, and atopic dermatitis. Cordycepin regulates several key signaling pathways. (Tan et al., 2020).
Cordycepin and Cancer: A systematic review identified cordycepin's inhibitory effects on cell survival and proliferation across a range of cancer types, attributing its therapeutic potential to mechanisms like apoptosis induction, cell cycle arrest, and signal transduction modulation, particularly through the PI3K/mTOR/AKT and ERK signaling pathways (Radhi et al., 2021).
Cordycepin's Role in AMPK Activation: The mechanism by which cordycepin activates AMP-activated protein kinase (AMPK) was clarified, revealing that cordycepin triphosphate serves as a direct activator of AMPK, highlighting its potential against metabolic disorders and its cytotoxic effects on cancer cells through this pathway (Hawley et al., 2020).
Cordycepin in Neuroinflammation: Cordycepin's anti-neuroinflammatory properties were explored, indicating its potential benefits against Alzheimer's disease, Parkinson's disease, and depression through the downregulation of adenosine A2 receptor, inhibition of microglial activation, and suppression of neuroinflammatory markers. This suggests cordycepin's role in managing CNS disorders associated with neuroinflammation (Govindula et al., 2021).
Troscriptions Tromune Bucchal Troches with Cordycepin.
