Elderberry (Sambucus nigra) is a traditional folk remedy used extensively throughout Europe.
Elderberry+ includes Andropgraphis, Echinacea, Vitamin C, Vitamin D, Zinc, Selenium and Manuka honey. Immune supporting herbs, vitamins and minerals.
In 400 BC, Hippocrates referred to the elder tree as his medicine chest. Today Elderberry is often recommended for use as a complementary therapy together with the classic antioxidant nutrients to support the natural process of recuperation.
Source: Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses
Our body uses antioxidants from plant origins to neutralise harmful free radicals and elderberry total antioxidant capacity is one of the highest of all the small fruits.
Source: Issues in new crops and new uses. 2007. J. Janick and A. Whipkey (eds.). ASHS Press, Alexandria, VA.
References to the berry can be found in many pharmacopeias over the centuries, including the Italian, Dutch, Portuguese, Croat-Slovak, German, Austrian, Swiss and Hungarian.5 The medicinal uses of the berry are almost as numerous as those who reported them: Johann Bauhin (1541-1613) mentions their use by peasants for dysentery and diarrhea; Adam Lonicer (1528- 1586) and Johann von Muralt (1638-1733) describe their use for inducing perspiration to remove toxins; and Conrad von Megenberg (1309-1374) first mentioned elder berry juice to increase resistance to illness.
Source: The ABC Clinical Guide to Elderberry
Elderberries have shown antibacterial and antiviral activities in in vitro . Two clinical trials using a liquid elderberry extract (Sambucol®, Israel) showed a reduction in symptoms and duration of influenza infection ]. A pilot trial with elderberry extract lozenges (HerbalScience, Singapore) also confirmed a beneficial effect on severity and duration of cold and flu like symptoms. In recent times, elderberry has gained popularity in research and the wider community due to its reported antioxidant, antidiabetic, anti-inflammatory and immune-modulating], as well as antidepressant properties.
Source: Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial
In folk medicine, elder berries have been used for their diaphoretic, laxative and diuretic properties (Uncini Manganelli et al. 2005; Merica et al. 2006) and to treat various illnesses such as stomach ache, sinus congestion, constipation, diarrhea, sore throat, common cold, and rheumatism (Novelli 2003; Uncini Manganelli et al. 2005). The flowers are said to have diaphoretic, anti-catarrhal, expectorant, circulatory stimulant, diuretic, and topical anti-inflammatory actions (Merica et al. 2006). Some of these properties seem justified since elderberry fruits contain tannins and viburnic acid, both known to have a positive effect on diarrhea, nasal congestion, and to improve respiration (Novelli 2003). Leaves and inner bark have also been used for their purgative, emetic, diuretic, laxative, topical emollient, expectorant, and diaphoretic action (Merica et al. 2006). Source
A clinical trial showed that a combination of echinacea herb and root extract supplemented with elderberry (Sambucus nigra L.) can be as effective as the conventional antiviral medicine oseltamivir for the early treatment of influenza.
Source: Effect of an Echinacea-Based Hot Drink Versus Oseltamivir in Influenza Treatment: A Randomized, Double-Blind, Double-Dummy, Multicenter, Noninferiority Clinical Trial
Supplementation with elderberry was found to substantially reduce upper respiratory symptoms. These findings present an alternative to antibiotic misuse for upper respiratory symptoms due to viral infections, and a potentially safer alternative to prescription drugs for routine cases of the common cold and influenza.
Source: Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials
As a result of the numerous problems associated with orthodox drugs, many plant species are now been revalued by researchers based on variation in plant species and their therapeutic chemical.
Andrographis (A. paniculata)
Andrographis, known as the 'king of bitters' has been extensively used as traditional medicine in Indian Ayurveda, Chinese TCM, Southeast Asia and Scandinavia.
Alternative names: Chiretta, Kalmegh, Creat, Chuanxinlian, Yijianxi, Lanhelian, Indian Echinacea.
Andrographis paniculata (kalmegh) present in South Asia has a strong treating capacity of viral respiratory infections in Ayurvedic and other medicinal systems.
Source: COVID-19: A promising cure for the global panic
Andrographis paniculata (Kalmegha in Hindi) is a herbaceous plant in the family Acanthaceae, native to India and Sri Lanka. It is sometimes called “Indian Echinacea” because it is believed to provide much the same benefits as Echinacea. Andrographolide, the major constituent of the extract is implicated towards its pharmacological activity. Studies have been conducted on the cellular processes and targets modulated by andrographolide treatment of immune cells. Andrographis was found to both reduce the symptoms and shorten the duration of colds in clinical trials . Andrographis paniculata also reduced the cold symptoms such as fatigue, sore throat, sore muscles, runny nose, headache, and lymph node swelling . Unlike the Echinacea, Andrographis does not have any side effects.
Source: Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud.
Herbal medicines have long been used to treat and prevent viral respiratory infections (VRI). The effects and benefits of a wide array of antiviral herbs are discussed in depth. The benefit of most of these herbs having built-in immune-stimulating and inflammation-modulating effects means that they can help prevent immune overreaction (“cytokine storm”) to VRI while still helping the immune system cope better with the infections.
Source: Herbs for Viral Respiratory Infections
The aerial parts possess most of the medicinal properties and are used to treat snakebites, insect stings, fever, sore throat, cough and stomachache.
Source: Andrographis use in Folk Medicine (Chart)
Different types of formulations, extracts and pure compounds obtained from this plant have been shown to possess biological activities including anti-microbial, anti-inflammatory, anti-oxidant, anti-diabetic, cytotoxicity, immune modulatory, sex hormone modulatory, liver enzyme modulatory, anti-malaria, anti-angiogenic and hepato-renal protective activity. Diterpenoid lactones including the bitter andrographolide are pure compounds derived from this plant with most promising biological activities.
Source: Harnessing the medicinal properties of Andrographis paniculata for diseases and beyond: a review of its phytochemistry and pharmacology
Andrographolide can prevent free-radical formation by protecting mitochondria or by inhibition of specific ROS-producing enzymes. It can also activate enzymatic or non-enzymatic antioxidants, mainly via the activation of the Nrf2 signaling pathway.
Source: Andrographolide, A Natural Antioxidant: An Update
A 2014 study suggests a quarter of South Australians are Vitamin D deficient (below 50 nmol/L)
A 2015 Melbourne study found 69% sufficiency in Summer, but 72% deficiency in Winter. The results suggest that the current Australian guidelines for sun exposure for 25(OH)D adequacy are effective for most in summer and ineffective for most in winter.
A 2019 Sydney study of office workers found 29% deficiency at the end of Summer and and 42% at the end of winter.
Extra vigilance is needed in winter to compensate for the reduction in daylight hours and outdoor activity.
Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide https://www.hindawi.com/journals/ecam/2013/846740/