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Oxaloacetate's neuro-protective activity has been shown to be related to its blood glutamate scavenging ability. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.
If you train your body at high intensities, it can become very efficient at shuttling lactic acid back up to the liver and converting it into glucose, after which the lactic acid can be “recycled” and used as a concentrated energy source by your muscle. This is called the Cori cycle.
So lactic acid can be used as a fuel source, and as you probably guessed, training at high intensities or with high amounts of resistance can teach your body how to more efficiently do that, but here’s the part where biohacking comes in:
A significant rate limiting step of converting lactic acid into glucose is the conversion of NAD into NADH, and in studies, acute oxaloacetate exposure enhances resistance to fatigue by allowing lactic acid to get recycled and converted to glucose at a much higher rate.
As a matter of fact, along with calorie restriction (which isn’t much fun, really), enhancing your Cori cycle efficiency is also one of the ways you can increase the enzyme AMPK, which up-regulates mitochondrial biogenesis.
Basically, this means that you can become a complete lactic acid metabolising endurance beast if you take oxaloacetate in supplement form 15-30 minutes prior to any endurance workout, preferably one that includes high intensity intervals.Read more: http://www.bengreenfieldfitness.com/2013/01/my-personal-notes-from-the-bulletproof-biohacking-conference/#ixzz2iyxayTYs
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